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Target
Dihydrofolate reductase
Ligand
BDBM50608614
Substrate
n/a
Meas. Tech.
ChEMBL_2274304
Ki
7.8±n/a nM
Citation
 He, J; Qiao, W; An, Q; Yang, T; Luo, Y Dihydrofolate reductase inhibitors for use as antimicrobial agents. Eur J Med Chem 195:0 (2020) [PubMed] 
Target
Name:
Dihydrofolate reductase
Synonyms:
Bacterial dihydrofolate reductase | DYR_ECOLI | Dihydrofolate Reductase (DHFR) | Tetrahydrofolate dehydrogenase | folA | tmrA
Type:
Enzyme
Mol. Mass.:
17991.61
Organism:
Escherichia coli
Description:
E. coli DHFR was expressed in BL21, and purified to homogeneity.
Residue:
159
Sequence:
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
  
Inhibitor
Name:
BDBM50608614
Synonyms:
CHEMBL1724189
Type:
Small organic molecule
Emp. Form.:
C17H16N6
Mol. Mass.:
304.3491
SMILES:
Nc1ccc(Cn2ccc3c2ccc2nc(N)nc(N)c32)cc1
Structure:
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