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Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50610162
Substrate
n/a
Meas. Tech.
ChEMBL_2280298
IC50
73±n/a nM
Citation
 Orsi, DL; Ferrara, SJ; Siegel, S; Friberg, A; Bouché, L; Pook, E; Lienau, P; Bluck, JP; Lemke, CT; Akcay, G; Stellfeld, T; Meyer, H; Pütter, V; Holton, SJ; Korr, D; Jerchel-Furau, I; Pantelidou, C; Strathdee, CA; Meyerson, M; Eis, K; Goldstein, JT Discovery and characterization of orally bioavailable 4-chloro-6-fluoroisophthalamides as covalent PPARG inverse-agonists. Bioorg Med Chem 78:0 (2023) [PubMed] 
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
Nr1c3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG_MOUSE | Pparg
Type:
PROTEIN
Mol. Mass.:
57593.55
Organism:
Mus musculus
Description:
ChEMBL_1453700
Residue:
505
Sequence:
MGETLGDSPVDPEHGAFADALPMSTSQEITMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISAPHYEDIPFTRADPMVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNRPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKNIPGFINLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKNLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKVLQKMTDLRQIVTEHVQLLHVIKKTETDMSLHPLLQEIYKDLY
  
Inhibitor
Name:
BDBM50610162
Synonyms:
CHEMBL5286386
Type:
Small organic molecule
Emp. Form.:
C24H20ClF3N2O3
Mol. Mass.:
476.875
SMILES:
CC(C)(O)c1ccc(NC(=O)c2cc(C(=O)NCc3ccc(F)c(F)c3)c(F)cc2Cl)cc1
Structure:
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