Reaction Details Report a problem with these data
Target
Interstitial collagenase
Ligand
BDBM50288716
Substrate
n/a
Meas. Tech.
ChEBML_101755
Ki
2090±n/a nM
Citation
Chapman, KT; Wales, J; Sahoo, SP; Niedzwiecki, LM; Izquierdo-Martin, M; Chang, BC; Harrison, RK; Stein, RL; Hagmann, WK Inhibition of matrix metalloproteinases by P1 substituted N-carboxyalkyl dipeptides Bioorg Med Chem Lett 6:329-332 (1996) Article
More Info.:
Target
Name:
Interstitial collagenase
Synonyms:
CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1)
Type:
Enzyme
Mol. Mass.:
54010.26
Organism:
Homo sapiens (Human)
Description:
P03956
Residue:
469
Sequence:
MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
Inhibitor
Name:
BDBM50288716
Synonyms:
(R)-4-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-[(S)-1-((S)-3-methyl-1-phenylcarbamoyl-butylcarbamoyl)-3-phenyl-propylamino]-butyric acid | CHEMBL111017
Type:
Small organic molecule
Emp. Form.:
C34H38N4O6
Mol. Mass.:
598.6887
SMILES:
CC(C)C[C@H](NC(=O)[C@H](CCc1ccccc1)N[C@H](CCN1C(=O)c2ccccc2C1=O)C(O)=O)C(=O)Nc1ccccc1