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Target
Renin
Ligand
BDBM50359179
Substrate
n/a
Meas. Tech.
ChEMBL_789821 (CHEMBL1925082)
pH
7.4±n/a
IC50
0.11±n/a nM
Comments
extracted
Citation
 Chen, A; Aspiotis, R; Campeau, LC; Cauchon, E; Chefson, A; Ducharme, Y; Falgueyret, JP; Gagné, S; Han, Y; Houle, R; Laliberté, S; Larouche, G; Lévesque, JF; McKay, D; Percival, D Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of spirocyclic piperidines. Bioorg Med Chem Lett 21:7399-404 (2011) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50359179
Synonyms:
CHEMBL1923116
Type:
Small organic molecule
Emp. Form.:
C25H28F2N2O2
Mol. Mass.:
426.4988
SMILES:
Cc1cccc(CN(C2CC2)C(=O)[C@H]2CNCC[C@@]22OCc3cc(F)c(F)cc23)c1C |r|
Structure:
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