Reaction Details Report a problem with these data
Target
Dihydroorotate dehydrogenase (fumarate)
Ligand
BDBM50206334
Substrate
n/a
Meas. Tech.
ChEMBL_519009 (CHEMBL942570)
IC50
>10000±n/a nM
Citation
 Dong, CK; Patel, V; Yang, JC; Dvorin, JD; Duraisingh, MT; Clardy, J; Wirth, DF Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors. Bioorg Med Chem Lett 19:972-5 (2009) [PubMed]  Article 
Target
Name:
Dihydroorotate dehydrogenase (fumarate)
Synonyms:
Dihydroorotate dehydrogenase | PYRD_YEAST | URA1
Type:
Enzyme
Mol. Mass.:
34799.00
Organism:
Saccharomyces cerevisiae
Description:
P28272
Residue:
314
Sequence:
MTASLTTKFLNNTYENPFMNASGVHCMTTQELDELANSKAGAFITKSATTLEREGNPEPRYISVPLGSINSMGLPNEGIDYYLSYVLNRQKNYPDAPAIFFSVAGMSIDENLNLLRKIQDSEFNGITELNLSCPNVPGKPQVAYDFDLTKETLEKVFAFFKKPLGVKLPPYFDFAHFDIMAKILNEFPLAYVNSINSIGNGLFIDVEKESVVVKPKNGFGGIGGEYVKPTALANVRAFYTRLRPEIKVIGTGGIKSGKDAFEHLLCGASMLQIGTELQKEGVKIFERIEKELKDIMEAKGYTSIDQFRGKLNSI
  
Inhibitor
Name:
BDBM50206334
Synonyms:
CHEMBL397686 | Diphenylene iodonium chloride | dibenziodolium chloride
Type:
Small organic molecule
Emp. Form.:
C12H8I
Mol. Mass.:
279.0958
SMILES:
[I+]1c2ccccc2-c2ccccc12
Structure:
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