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Target
5-hydroxytryptamine receptor 2B
Ligand
BDBM50302212
Substrate
n/a
Meas. Tech.
ChEMBL_599590 (CHEMBL1040202)
Ki
610±n/a nM
Citation
 Rotella, DP; McFarlane, GR; Greenfield, A; Grosanu, C; Robichaud, AJ; Denny, RA; Feenstra, RW; Núñez-García, S; Reinders, JH; Neut, Mv; McCreary, A; Kruse, CG; Sullivan, K; Pruthi, F; Lai, M; Zhang, J; Kowal, DM; Carrick, T; Grauer, SM; Navarra, RL; Graf, R; Brennan, J; Marquis, KL; Pausch, MH Tetrahydrocarbazole-based serotonin reuptake inhibitor/dopamine D2 partial agonists for the potential treatment of schizophrenia. Bioorg Med Chem Lett 19:5552-5 (2009) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2B
Synonyms:
5-HT-2B | 5-HT2B | 5-hydroxytryptamine (serotonin) receptor 2B [Homo sapiens] | 5-hydroxytryptamine receptor 2B (5-HT2B) | 5-hydroxytryptamine receptor 2C (5HT2C) | 5HT2B_HUMAN | HTR2B | Serotonin (5-HT3) receptor | Serotonin 2b (5-HT2b) receptor | Serotonin Receptor 2B
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
54312.47
Organism:
Homo sapiens (Human)
Description:
Receptor binding assays were performed using human clone stably expressed in CHO cells.
Residue:
481
Sequence:
MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV
  
Inhibitor
Name:
BDBM50302212
Synonyms:
(3S)-3-((3-( 6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-2-yl)propylamino)methyl)-7,9-dihydro-2H-[1,4]dioxino[2,3-e]indol-8(3H)-one | (3S)-3-((3-(6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-2-yl)propylamino)methyl)-7,9-dihydro-2H-[1,4]dioxino[2,3-e]indol-8(3H)-one | CHEMBL566379
Type:
Small organic molecule
Emp. Form.:
C26H28FN3O3
Mol. Mass.:
449.5172
SMILES:
Fc1ccc2[nH]c3CC(CCCNC[C@H]4COc5c6CC(=O)Nc6ccc5O4)CCc3c2c1 |r|
Structure:
Search PDB for entries with ligand similarity: