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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50424653
Substrate
n/a
Meas. Tech.
ChEMBL_934123 (CHEMBL2318876)
EC50
>10000±n/a nM
Citation
 Melancon, BJ; Poslusney, MS; Gentry, PR; Tarr, JC; Sheffler, DJ; Mattmann, ME; Bridges, TM; Utley, TJ; Daniels, JS; Niswender, CM; Conn, PJ; Lindsley, CW; Wood, MR Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137: continued optimization of an MLPCN probe molecule. Bioorg Med Chem Lett 23:412-6 (2012) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50424653
Synonyms:
CHEMBL2313495
Type:
Small organic molecule
Emp. Form.:
C22H24N4O
Mol. Mass.:
360.4522
SMILES:
CN(C)C1(C)C(=O)N(Cc2ccc(cc2)-c2cnn(C)c2)c2ccccc12
Structure:
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