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Target
Neuromedin-K receptor
Ligand
BDBM50081196
Substrate
n/a
Meas. Tech.
ChEMBL_1475774 (CHEMBL3425007)
Ki
6.3±n/a nM
Citation
 Hoveyda, HR; Fraser, GL; Roy, MO; Dutheuil, G; Batt, F; El Bousmaqui, M; Korac, J; Lenoir, F; Lapin, A; Noël, S; Blanc, S Discovery and optimization of novel antagonists to the human neurokinin-3 receptor for the treatment of sex-hormone disorders (Part I). J Med Chem 58:3060-82 (2015) [PubMed]  Article 
Target
Name:
Neuromedin-K receptor
Synonyms:
NK-3 receptor | TACR3 | Uncharacterized protein | nk-3
Type:
PROTEIN
Mol. Mass.:
51998.78
Organism:
Macaca mulatta
Description:
ChEMBL_109608
Residue:
463
Sequence:
MATLPAAETWIDGGGGVGADAVNLTASLAAGAATGTVETGWLQLLDQAGNLSSSPSALGLPVASPAPSQPRANLTNQFVQPSWRIALWSLAYGVVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLVNFIYALHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKTKVMPGRTLCFVQWPEGPKQHFTYHIIVIILVYCFPLLIMGITYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKMMIIVVMTFAICWLPYHIYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIKVSSYDELELKTTRFHPTRQSSMYTVTRMESMTVMFDPSDADTARSSRKKRATPRDPSFNGCSRRNSKSASTTSSFISSPYTSVDE
  
Inhibitor
Name:
BDBM50081196
Synonyms:
CHEMBL3422015 | US10065961, Compound 13 | US10683295, Compound 13 | US10941151, Compound 13 | US9475814, 13
Type:
Small organic molecule
Emp. Form.:
C23H23N5O2S
Mol. Mass.:
433.526
SMILES:
CC(C)c1nc(co1)-c1nnc2[C@@H](C)N(CCn12)C(=O)c1ccc(cc1)-c1cccs1 |r|
Structure:
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