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Target
Sialidase-2
Ligand
BDBM50182216
Substrate
n/a
Meas. Tech.
ChEMBL_1585707 (CHEMBL3821004)
IC50
>1000000±n/a nM
Citation
 Sriwilaijaroen, N; Magesh, S; Imamura, A; Ando, H; Ishida, H; Sakai, M; Ishitsubo, E; Hori, T; Moriya, S; Ishikawa, T; Kuwata, K; Odagiri, T; Tashiro, M; Hiramatsu, H; Tsukamoto, K; Miyagi, T; Tokiwa, H; Kiso, M; Suzuki, Y A Novel Potent and Highly Specific Inhibitor against Influenza Viral N1-N9 Neuraminidases: Insight into Neuraminidase-Inhibitor Interactions. J Med Chem 59:4563-77 (2016) [PubMed]  Article 
Target
Name:
Sialidase-2
Synonyms:
Cytosolic sialidase | N-acetyl-alpha-neuraminidase 2 | NEU2 | NEUR2_HUMAN | Sialidase 2 | Sialidase-2
Type:
PROTEIN
Mol. Mass.:
42256.20
Organism:
Homo sapiens (Human)
Description:
ChEMBL_960638
Residue:
380
Sequence:
MASLPVLQKESVFQSGAHAYRIPALLYLPGQQSLLAFAEQRASKKDEHAELIVLRRGDYDAPTHQVQWQAQEVVAQARLDGHRSMNPCPLYDAQTGTLFLFFIAIPGQVTEQQQLQTRANVTRLCQVTSTDHGRTWSSPRDLTDAAIGPAYREWSTFAVGPGHCLQLHDRARSLVVPAYAYRKLHPIQRPIPSAFCFLSHDHGRTWARGHFVAQDTLECQVAEVETGEQRVVTLNARSHLRARVQAQSTNDGLDFQESQLVKKLVEPPPQGCQGSVISFPSPRSGPGSPAQWLLYTHPTHSWQRADLGAYLNPRPPAPEAWSEPVLLAKGSCAYSDLQSMGTGPDGSPLFGCLYEANDYEEIVFLMFTLKQAFPAEYLPQ
  
Inhibitor
Name:
BDBM50182216
Synonyms:
CHEMBL3819510
Type:
Small organic molecule
Emp. Form.:
C19H30F3N5O9
Mol. Mass.:
529.4648
SMILES:
OC(=O)C(F)(F)F.[H][C@]1(OC(=C[C@H](NC(N)=N)[C@H]1NC(C)=O)C(O)=O)[C@H](O)[C@H](O)CNC(=O)CCCC |r,c:9|
Structure:
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