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Target
Histone acetyltransferase KAT2B
Ligand
BDBM152260
Substrate
n/a
Meas. Tech.
ChEMBL_1632236 (CHEMBL3874942)
Kd
360000±n/a nM
Citation
 Navratilova, I; Aristotelous, T; Picaud, S; Chaikuad, A; Knapp, S; Filappakopoulos, P; Hopkins, AL Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening. ACS Med Chem Lett 7:1213-1218 (2016) [PubMed]  Article 
Target
Name:
Histone acetyltransferase KAT2B
Synonyms:
Histone acetyltransferase KAT2A/KAT2B | Histone acetyltransferase PCAF | KAT2B | KAT2B_HUMAN | PCAF
Type:
PROTEIN
Mol. Mass.:
93045.76
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1502838
Residue:
832
Sequence:
MSEAGGAGPGGCGAGAGAGAGPGALPPQPAALPPAPPQGSPCAAAAGGSGACGPATAVAAAGTAEGPGGGGSARIAVKKAQLRSAPRAKKLEKLGVYSACKAEESCKCNGWKNPNPSPTPPRADLQQIIVSLTESCRSCSHALAAHVSHLENVSEEEMNRLLGIVLDVEYLFTCVHKEEDADTKQVYFYLFKLLRKSILQRGKPVVEGSLEKKPPFEKPSIEQGVNNFVQYKFSHLPAKERQTIVELAKMFLNRINYWHLEAPSQRRLRSPNDDISGYKENYTRWLCYCNVPQFCDSLPRYETTQVFGRTLLRSVFTVMRRQLLEQARQEKDKLPLEKRTLILTHFPKFLSMLEEEVYSQNSPIWDQDFLSASSRTSQLGIQTVINPPPVAGTISYNSTSSSLEQPNAGSSSPACKASSGLEANPGEKRKMTDSHVLEEAKKPRVMGDIPMELINEVMSTITDPAAMLGPETNFLSAHSARDEAARLEERRGVIEFHVVGNSLNQKPNKKILMWLVGLQNVFSHQLPRMPKEYITRLVFDPKHKTLALIKDGRVIGGICFRMFPSQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKHDILNFLTYADEYAIGYFKKQGFSKEIKIPKTKYVGYIKDYEGATLMGCELNPRIPYTEFSVIIKKQKEIIKKLIERKQAQIRKVYPGLSCFKDGVRQIPIESIPGIRETGWKPSGKEKSKEPRDPDQLYSTLKSILQQVKSHQSAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLKNRYYVSKKLFMADLQRVFTNCKEYNPPESEYYKCANILEKFFFSKIKEAGLIDK
  
Inhibitor
Name:
BDBM152260
Synonyms:
US8993552, 1F4 Compound 44
Type:
Small organic molecule
Emp. Form.:
C10H10N4O
Mol. Mass.:
202.2126
SMILES:
Cc1nn(nc1C(N)=O)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: