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Target
Lysine-specific demethylase 5D [1-760]
Ligand
BDBM50396019
Substrate
n/a
Meas. Tech.
Formaldehyde Dehydrogenase-Coupled Demethylase (FDH) Assay
Temperature
298.15±n/a K
IC50
5.3e+4± 8e+3 nM
Comments
extracted
Citation
 Horton, JR; Liu, X; Gale, M; Wu, L; Shanks, JR; Zhang, X; Webber, PJ; Bell, JS; Kales, SC; Mott, BT; Rai, G; Jansen, DJ; Henderson, MJ; Urban, DJ; Hall, MD; Simeonov, A; Maloney, DJ; Johns, MA; Fu, H; Jadhav, A; Vertino, PM; Yan, Q; Cheng, X Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds. Cell Chem Biol 23:769-81 (2016) [PubMed]  Article 
Target
Name:
Lysine-specific demethylase 5D [1-760]
Synonyms:
HY | HYA | JARID1D | KDM5D | KDM5D_HUMAN | KIAA0234 | Lysine-specific demethylase 5D (KDM5D(aa 1-760)-AP) | SMCY
Type:
Protein
Mol. Mass.:
87351.60
Organism:
Homo sapiens (Human)
Description:
Truncation 1-760 aa. Contains deletion of ARID and PhD1 domains.
Residue:
760
Sequence:
MEPGCDEFLPPPECPVFEPSWAEFQDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEVDNFRFTPRVQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERKILDLYSLSKIVIEEGGYEAICKDRRWARVAQRLHYPPGKNIGSLLRSHYERIIYPYEMFQSGANHVQCNTHPFDNEVKDKEYKPHSIPLRQSVQPSKFSSYSRRAKRLQPDPEPTEEDIEKHPELKKLQIYGPGPKMMGLGLMAKDKDKTVHKKVTCPPTVTVKDEQSGGGNVSSTLLKQHLSLEPCTKTTMQLRKNHSSAQFIDSYICQVCSRGDEDDKLLFCDGCDDNYHIFCLLPPLPEIPRGIWRCPKCILAECKQPPEAFGFEQATQEYSLQSFGEMADSFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVTVEYGADIHSKEFGSGFPVSNSKQNLSPEEKEYATSGWNLNVMPVLDQSVLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMKMLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAAFPETLDLNLAVAVHKEMFIMVQEERRLRKALLEKGVTEAEREAFELLPDDERQCIKCKTTCFLSALACYDCPDGLVCLSHINDLCKCSSSRQYLRYRYTLDELPTMLHKLKIRAESF
  
Inhibitor
Name:
BDBM50396019
Synonyms:
4'-(phenethylcarbamoyl)-[2,2'-bipyridine]-4-carboxylic acid (N3) | CHEMBL2169917
Type:
Small organic molecule
Emp. Form.:
C20H17N3O3
Mol. Mass.:
347.3673
SMILES:
OC(=O)c1ccnc(c1)-c1cc(ccn1)C(=O)NCCc1ccccc1
Structure:
Search PDB for entries with ligand similarity: