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Target
Toll-like receptor 8
Ligand
BDBM443627
Substrate
n/a
Meas. Tech.
Inhibition Reporter Assay
IC50
4.20±n/a nM
Citation
 Dyckman, AJ; Dodd, DS; Haque, TS; Lombardo, LJ; Macor, JE; Mussari, CP; Pasunoori, L; Poss, MA; Kumar, SR; Posy, SL; Tortolani, DR; Whiteley, BK; Sistla, RK; Hegde, S; Ramachandra Reddy, AK Pyridyl substituted indole compounds US Patent  US10660877 Publication Date 5/26/2020 
Target
Name:
Toll-like receptor 8
Synonyms:
CD_antigen: CD288 | TLR8 | TLR8_HUMAN | TRL8
Type:
Enzyme
Mol. Mass.:
119828.77
Organism:
Homo sapiens (Human)
Description:
Q9NR97
Residue:
1041
Sequence:
MENMFLQSSMLTCIFLLISGSCELCAEENFSRSYPCDEKKQNDSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDIGDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITTMVMLAALAHHLFYWDVWFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINELRYHLEESRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAFYLALQRLMDENMDVIIFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFWQTLRNVVLTENDSRYNNMYVDSIKQY
  
Inhibitor
Name:
BDBM443627
Synonyms:
US10660877, Example 211
Type:
Small organic molecule
Emp. Form.:
C31H42N4O2
Mol. Mass.:
502.6908
SMILES:
CC(C)c1c([nH]c2ccc(cc12)C1CCN(CC(=O)NC2CCC(O)CC2)CC1)-c1cc(C)nc(C)c1 |(.14,-4.33,;1.65,-4.01,;2.68,-5.16,;2.13,-2.55,;1.22,-1.3,;2.13,-.06,;3.59,-.53,;4.92,.24,;6.26,-.53,;6.26,-2.07,;4.92,-2.84,;3.59,-2.07,;7.59,-2.84,;8.92,-2.07,;10.26,-2.84,;10.26,-4.38,;11.59,-5.15,;11.59,-6.69,;10.26,-7.46,;12.93,-7.46,;12.93,-9,;14.26,-9.77,;14.26,-11.31,;12.93,-12.08,;12.93,-13.62,;11.59,-11.31,;11.59,-9.77,;8.92,-5.15,;7.59,-4.38,;-.32,-1.3,;-1.09,-2.64,;-2.63,-2.64,;-3.4,-3.97,;-3.4,-1.3,;-2.63,.03,;-3.4,1.36,;-1.09,.03,)|
Structure:
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