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Target
Membrane primary amine oxidase
Ligand
BDBM389897
Substrate
n/a
Meas. Tech.
Biological Assay
IC50
<50±n/a nM
Citation
 Espensen, M; Patient, L; Evans, D; Simpson, I; Savory, E Imidazo[4,5-c]pyridine and pyrrolo[2,3-c]pyridine derivatives as SSAO inhibitors US Patent  US10766897 Publication Date 9/8/2020 
Target
Name:
Membrane primary amine oxidase
Synonyms:
AOC3 | AOC3_HUMAN | Amine oxidase, copper containing | Semicarbazide-sensitive amine oxidase (SSAO) | Semicarbazide-sensitive amine oxidase/ Vascular adhesion protein 1 (SSAO/VAP-1) | VAP1 | Vascular adhesion protein 1 (VAP-1)
Type:
Protein
Mol. Mass.:
84620.86
Organism:
Homo sapiens (Human)
Description:
Q16853
Residue:
763
Sequence:
MNQKTILVLLILAVITIFALVCVLLVGRGGDGGEPSQLPHCPSVSPSAQPWTHPGQSQLFADLSREELTAVMRFLTQRLGPGLVDAAQARPSDNCVFSVELQLPPKAAALAHLDRGSPPPAREALAIVFFGRQPQPNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLFQEYLDIDQMIFNRELPQASGLLHHCCFYKHRGRNLVTMTTAPRGLQSGDRATWFGLYYNISGAGFFLHHVGLELLVNHKALDPARWTIQKVFYQGRYYDSLAQLEAQFEAGLVNVVLIPDNGTGGSWSLKSPVPPGPAPPLQFYPQGPRFSVQGSRVASSLWTFSFGLGAFSGPRIFDVRFQGERLVYEISLQEALAIYGGNSPAAMTTRYVDGGFGMGKYTTPLTRGVDCPYLATYVDWHFLLESQAPKTIRDAFCVFEQNQGLPLRRHHSDLYSHYFGGLAETVLVVRSMSTLLNYDYVWDTVFHPSGAIEIRFYATGYISSAFLFGATGKYGNQVSEHTLGTVHTHSAHFKVDLDVAGLENWVWAEDMVFVPMAVPWSPEHQLQRLQVTRKLLEMEEQAAFLVGSATPRYLYLASNHSNKWGHPRGYRIQMLSFAGEPLPQNSSMARGFSWERYQLAVTQRKEEEPSSSSVFNQNDPWAPTVDFSDFINNETIAGKDLVAWVTAGFLHIPHAEDIPNTVTVGNGVGFFLRPYNFFDEDPSFYSADSIYFRGDQDAGACEVNPLACLPQAAACAPDLPAFSHGGFSHN
  
Inhibitor
Name:
BDBM389897
Synonyms:
4-{5-[3-(2-Fluorophenyl)-3H- imidazo[4,5-c]pyridin-2- yl]pyridin-2-yl}morpholine | US10766897, Compound 68 | US10968223, Compound 68 | US9951068, Compound 68
Type:
Small organic molecule
Emp. Form.:
C21H18FN5O
Mol. Mass.:
375.3989
SMILES:
Fc1ccccc1-n1c(nc2ccncc12)-c1ccc(nc1)N1CCOCC1 |(-5.18,-1.34,;-3.7,-1.74,;-3.3,-3.23,;-1.81,-3.62,;-.72,-2.54,;-1.12,-1.05,;-2.61,-.65,;-3.01,.84,;-2.1,2.08,;-3.01,3.33,;-4.47,2.85,;-5.8,3.62,;-7.14,2.85,;-7.14,1.31,;-5.8,.54,;-4.47,1.31,;-.56,2.08,;.21,.75,;1.75,.75,;2.52,2.08,;1.75,3.42,;.21,3.42,;4.06,2.08,;4.83,.75,;6.37,.75,;7.14,2.08,;6.37,3.42,;4.83,3.42,)|
Structure:
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