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Target
Nuclear receptor ROR-gamma
Ligand
BDBM302244
Substrate
n/a
Meas. Tech.
Reporter Gene Assay
IC50
275±n/a nM
Citation
 Bakonyi, J; Brunette, SR; Collin, D; Hughes, RO; Li, X; Liang, S; Sibley, R; Turner, MR; Wu, L; Zhang, Q Compounds as modulators of RORγ US Patent  US9598415 Publication Date 3/21/2017 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM302244
Synonyms:
US9598415, 156
Type:
Small organic molecule
Emp. Form.:
C26H30N8O3S
Mol. Mass.:
534.633
SMILES:
CCS(=O)(=O)c1ccc(CNc2nc3cnc(nc3n(CC(C)C)c2=O)-c2c(C)ncnc2C2CC2)cn1 |$;;;;;;;;;;HN;;;;;;;;;;;;;;;;;;;;;;;;;;;$|
Structure:
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