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Target
Kinesin-like protein KIF11
Ligand
BDBM509099
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
0.446±n/a nM
Citation
 Lerchen, H; Rebstock, A; Cancho Grande, Y; Wittrock, S; Berndt, S; Gritzan, U; Fitting, J; Stelte-Ludwig, B; Jones, P; Mahlert, C; Votsmeier, C; Schönfeld, D; Trautwein, M; Weber, E; Pawlowski, N; Greven, S; Glück, JM; Hammer, S; Dietz, L; Märsch, S Antibody drug conjugates of kinesin spindel protein (KSP) inhibitors with antiB7H3-antibodies US Patent  US11071788 Publication Date 7/27/2021 
Target
Name:
Kinesin-like protein KIF11
Synonyms:
EG5 | KIF11 | KIF11_HUMAN | KNSL1 | Kinesin Spindle Protein Eg5 | Kinesin-like protein 1 | TRIP5 | kinesin spindle protein
Type:
PROTEIN
Mol. Mass.:
119138.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1457426
Residue:
1056
Sequence:
MASQPNSSAKKKEEKGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEVNQKLTKKALIKEYTEEIERLKRDLAAAREKNGVYISEENFRVMSGKLTVQEEQIVELIEKIGAVEEELNRVTELFMDNKNELDQCKSDLQNKTQELETTQKHLQETKLQLVKEEYITSALESTEEKLHDAASKLLNTVEETTKDVSGLHSKLDRKKAVDQHNAEAQDIFGKNLNSLFNNMEELIKDGSSKQKAMLEVHKTLFGNLLSSSVSALDTITTVALGSLTSIPENVSTHVSQIFNMILKEQSLAAESKTVLQELINVLKTDLLSSLEMILSPTVVSILKINSQLKHIFKTSLTVADKIEDQKKELDGFLSILCNNLHELQENTICSLVESQKQCGNLTEDLKTIKQTHSQELCKLMNLWTERFCALEEKCENIQKPLSSVQENIQQKSKDIVNKMTFHSQKFCADSDGFSQELRNFNQEGTKLVEESVKHSDKLNGNLEKISQETEQRCESLNTRTVYFSEQWVSSLNEREQELHNLLEVVSQCCEASSSDITEKSDGRKAAHEKQHNIFLDQMTIDEDKLIAQNLELNETIKIGLTKLNCFLEQDLKLDIPTGTTPQRKSYLYPSTLVRTEPREHLLDQLKRKQPELLMMLNCSENNKEETIPDVDVEEAVLGQYTEEPLSQEPSVDAGVDCSSIGGVPFFQHKKSHGKDKENRGINTLERSKVEETTEHLVTKSRLPLRAQINL
  
Inhibitor
Name:
BDBM509099
Synonyms:
4-{[(1R)-2-({2-[(3-Aminopropyl) {(1R)-1-[1-benzyl-4-(2,5-difluorophenyl)-1H-pyrrol-2-yl]-2,2-dimethylpropyl}amino]-2-oxoethyl}sulphanyl)-1-carboxyethyl]amino}-4-oxobutanoic acid/trifluoroacetic acid (1:1) | US11071788, Example M12
Type:
Small organic molecule
Emp. Form.:
C34H42F2N4O6S
Mol. Mass.:
672.782
SMILES:
CC(C)(C)[C@@H](N(CCCN)C(=O)CSC[C@H](NC(=O)CCC(O)=O)C(O)=O)c1cc(cn1Cc1ccccc1)-c1cc(F)ccc1F |r|
Structure:
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