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Target
Tyrosine-protein kinase
Ligand
BDBM50204290
Substrate
n/a
Meas. Tech.
Radiometric Protein Kinase Assay
IC50
4830±n/a nM
Citation
 Griebenow, N; Mottier, MD; Beddies, G; Cramer, J; Bömer, U; Heisler, I Use of fused heteroaromatic pyrrolidones for treatment and prevention of diseases in animals US Patent  US11077111 Publication Date 8/3/2021 
Target
Name:
Tyrosine-protein kinase
Synonyms:
Janus kinase 2 | Tyrosine-protein kinase JAK2
Type:
Protein
Mol. Mass.:
127851.46
Organism:
Dog
Description:
A0A8C0RXK6
Residue:
1103
Sequence:
MTLGQQDVSKVLLGPLSPYTFQSQAREQDVNCCASAEDGPSSPSREGITPVYHSMFALMSETERIWYPPNHVFHIDESTKHNVLYRIRFYFPYWYCNGSNRTYRHGISRGAEAPLLDDFVMAYLFAQWRHDFLHGWIKIPVTHETQEECLGMAVLDMMRLAKEKDQTPLDIYSSISYKTFLPKCVRAKIQDYHILTRKRIRYRFRRFIEQFSHCKATARNLKLKYLINLETLQSAFYTEQFEVKEPGRGPSGEEIFATIIITGNGGIQWSRGKRKESETLTEQDLQLYCDFPDIIDVTIKQASQEGSNESRIVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPMVLENIQSNCHGPILMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAIERENVIEYKHCLITKNENGEYNLSGTKKSFRNLKDLLNCYHMETVRSDSIIFQFTKCCPPKLKDKSNLLVFRTNGVSDVPTSPTLQRHNNVNQMVFHKIRNEDLMFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINIFWKLEVAKQLAWAMHFLEEKALIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWTELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFPGAFEDQDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYLIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
  
Inhibitor
Name:
BDBM50204290
Synonyms:
CHEMBL3979920 | US11077111, Compound IIIa | US20230295171, Example 102
Type:
Small organic molecule
Emp. Form.:
C17H21FN6O
Mol. Mass.:
344.3866
SMILES:
Cn1cc(cn1)-c1nc(N[C@@H]2CCCC[C@@H]2N)c(F)c2CNC(=O)c12 |r|
Structure:
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