Reaction Details Report a problem with these data
Target
Alpha-synuclein
Ligand
BDBM510819
Substrate
n/a
Meas. Tech.
In-Vitro Fluorescence Polarization Assay
IC50
370±n/a nM
Citation
 Wrasidlo, W; Stocking, EM Heteroaryl amides as inhibitors of protein aggregation US Patent  US11078196 Publication Date 8/3/2021 
Target
Name:
Alpha-synuclein
Synonyms:
NACP | PARK1 | SNCA | SYUA_HUMAN
Type:
Protein
Mol. Mass.:
14451.42
Organism:
Homo sapiens (Human)
Description:
P37840
Residue:
140
Sequence:
MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA
  
Inhibitor
Name:
BDBM510819
Synonyms:
N-(1-(1H-Indol-3-yl)hexan-2- yl)-5-(4-methylpiperazin-1-yl)- 1,3,4-thiadiazole-2-carboxamide | US11078196, Ex. 7
Type:
Small organic molecule
Emp. Form.:
C22H30N6O2
Mol. Mass.:
410.5126
SMILES:
CCCCC(Cc1c[nH]c2ccccc12)NC(=O)c1nnc(o1)N1CCN(C)CC1
Structure:
Search PDB for entries with ligand similarity: