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Target
CREB-binding protein [1081-1197]
Ligand
BDBM511382
Substrate
n/a
Meas. Tech.
CBP AlphaScreen Assay
IC50
16.0±n/a nM
Citation
 Le, K; Soth, MJ; Jones, P; Cross, JB; Carroll, CL; McAfoos, TJ; Mandal, PK Imidazopiperazine inhibitors of transcription activating proteins US Patent  US11058688 Publication Date 7/13/2021 
Target
Name:
CREB-binding protein [1081-1197]
Synonyms:
CBP | CBP_HUMAN | CREB-binding protein (CBP)(1081-1197) | CREBBP
Type:
Enzyme Catalytic Domain
Mol. Mass.:
13987.94
Organism:
Homo sapiens (Human)
Description:
Q92793[1081-1197]
Residue:
117
Sequence:
RKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLG
  
Inhibitor
Name:
BDBM511382
Synonyms:
1-(7-fluoro-3-(tetrahydro- 2H-pyran-4- yl)isoquinolin-8-yl)-N- methyl-3-(tetrahydro-2H- pyran-4-yl)-5,6- dihydroimidazo[1,5- a]pyrazine-7(8H)- carboxamide | US11058688, Example 83
Type:
Small organic molecule
Emp. Form.:
C27H32FN5O3
Mol. Mass.:
493.5731
SMILES:
CNC(=O)N1CCn2c(C1)c(nc2C1CCOCC1)-c1c(F)ccc2cc(ncc12)C1CCOCC1 |(-5.55,.44,;-4.22,1.21,;-2.89,.44,;-2.89,-1.1,;-1.55,1.21,;-1.55,2.75,;-.22,3.52,;1.11,2.75,;1.11,1.21,;-.22,.44,;2.58,.73,;3.48,1.98,;2.58,3.22,;2.98,4.71,;4.47,5.11,;4.86,6.6,;3.77,7.69,;2.29,7.29,;1.89,5.8,;2.98,-.75,;4.47,-1.15,;5.55,-.06,;4.86,-2.64,;3.77,-3.73,;2.29,-3.33,;1.2,-4.42,;-.29,-4.02,;-.69,-2.53,;.4,-1.45,;1.89,-1.84,;-1.38,-5.11,;-2.87,-4.71,;-3.95,-5.8,;-3.56,-7.29,;-2.07,-7.69,;-.98,-6.6,)|
Structure:
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