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Target
S-adenosylmethionine synthase isoform type-2
Ligand
BDBM508343
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
<200±n/a nM
Citation
 Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE 2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors US Patent  US11084798 Publication Date 8/10/2021 
Target
Name:
S-adenosylmethionine synthase isoform type-2
Synonyms:
AMS2 | AdoMet synthase 2 | MAT 2 | MAT-II | MAT2A | MATA2 | METK2_HUMAN | Methionine adenosyltransferase 2 | Methionine adenosyltransferase II
Type:
Protein
Mol. Mass.:
43659.65
Organism:
Human
Description:
P31153
Residue:
395
Sequence:
MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
  
Inhibitor
Name:
BDBM508343
Synonyms:
7-chloro-1-(imidazo[1,2-a]pyridin-5- yl)-4-(methylamino)quinazolin-2(1H)- one | US11046691, Compound 654 | US11084798, Cpd No 654 | US11130759, Cpd. No. 654
Type:
Small organic molecule
Emp. Form.:
C16H12ClN5O
Mol. Mass.:
325.752
SMILES:
CNc1nc(=O)n(-c2cccc3nccn23)c2cc(Cl)ccc12 |(,5,;1.33,4.23,;1.33,2.69,;2.67,1.92,;2.67,.38,;4,-.38,;1.33,-.39,;1.33,-1.93,;2.67,-2.69,;2.67,-4.23,;1.33,-5,;,-4.23,;-1.46,-4.71,;-2.37,-3.47,;-1.46,-2.22,;,-2.69,;,.38,;-1.33,-.38,;-2.67,.38,;-4,-.38,;-2.67,1.93,;-1.33,2.69,;,1.92,)|
Structure:
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