Reaction Details Report a problem with these data
Target
Ubiquitin carboxyl-terminal hydrolase 30
Ligand
BDBM512288
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
550±n/a nM
Citation
 Stockley, ML; Kemp, MI; Madin, A Cyanopyrrolidine derivatives with activity as inhibitors of USP30 US Patent  US11084821 Publication Date 8/10/2021 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 30
Synonyms:
Deubiquitinating enzyme 30 | UBP30_HUMAN | USP30 | Ub-specific protease 30 | Ubiquitin carboxyl-terminal hydrolase 30 (USP30) | Ubiquitin thioesterase 30 | Ubiquitin-specific-processing protease 30
Type:
Protein
Mol. Mass.:
58522.90
Organism:
Homo sapiens (Human)
Description:
Q70CQ3
Residue:
517
Sequence:
MLSSRAEAAMTAADRAIQRFLRTGAAVRYKVMKNWGVIGGIAAALAAGIYVIWGPITERKKRRKGLVPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTLLHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQPRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDIYKYHLLGHKPSQHNPKLNKNPGPTLELQDGPGAPTPVLNQPGAPKTQIFMNGACSPSLLPTLSAPMPFPLPVVPDYSSSTYLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVLSSSAYLLFYERVLSRMQHQSQECKSEE
  
Inhibitor
Name:
BDBM512288
Synonyms:
(3aR,6aR)-1-(6-Methoxy-1H-benzo[d]imidazol-2-yl)hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carbonitrile | US11084821, Example 17
Type:
Small organic molecule
Emp. Form.:
C15H17N5O
Mol. Mass.:
283.3284
SMILES:
COc1ccc2nc([nH]c2c1)N1CC[C@@H]2CN(C[C@H]12)C#N
Structure:
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