Reaction Details Report a problem with these data
Target
Ubiquitin carboxyl-terminal hydrolase 30
Ligand
BDBM512296
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
5.5±n/a nM
Citation
Stockley, ML; Kemp, MI; Madin, A Cyanopyrrolidine derivatives with activity as inhibitors of USP30 US Patent US11084821 Publication Date 8/10/2021
More Info.:
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 30
Synonyms:
Deubiquitinating enzyme 30 | UBP30_HUMAN | USP30 | Ub-specific protease 30 | Ubiquitin carboxyl-terminal hydrolase 30 (USP30) | Ubiquitin thioesterase 30 | Ubiquitin-specific-processing protease 30
Type:
Protein
Mol. Mass.:
58522.90
Organism:
Homo sapiens (Human)
Description:
Q70CQ3
Residue:
517
Sequence:
MLSSRAEAAMTAADRAIQRFLRTGAAVRYKVMKNWGVIGGIAAALAAGIYVIWGPITERKKRRKGLVPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTLLHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQPRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDIYKYHLLGHKPSQHNPKLNKNPGPTLELQDGPGAPTPVLNQPGAPKTQIFMNGACSPSLLPTLSAPMPFPLPVVPDYSSSTYLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVLSSSAYLLFYERVLSRMQHQSQECKSEE
Inhibitor
Name:
BDBM512296
Synonyms:
US11084821, Example 25 | rac-(4aR,7aS)-4-(5-(3-Cyanophenyl)pyrazin-2-yl)hexahydropyrrolo[3,4-b][1,4]oxazine-6(2H)-carbonitrile
Type:
Small organic molecule
Emp. Form.:
C18H16N6O
Mol. Mass.:
332.3592
SMILES:
N#CN1C[C@@H]2OCCN([C@@H]2C1)c1cnc(cn1)-c1cccc(c1)C#N