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Target
Ubiquitin carboxyl-terminal hydrolase 30
Ligand
BDBM512298
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
55±n/a nM
Citation
 Stockley, ML; Kemp, MI; Madin, A Cyanopyrrolidine derivatives with activity as inhibitors of USP30 US Patent  US11084821 Publication Date 8/10/2021 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 30
Synonyms:
Deubiquitinating enzyme 30 | UBP30_HUMAN | USP30 | Ub-specific protease 30 | Ubiquitin carboxyl-terminal hydrolase 30 (USP30) | Ubiquitin thioesterase 30 | Ubiquitin-specific-processing protease 30
Type:
Protein
Mol. Mass.:
58522.90
Organism:
Homo sapiens (Human)
Description:
Q70CQ3
Residue:
517
Sequence:
MLSSRAEAAMTAADRAIQRFLRTGAAVRYKVMKNWGVIGGIAAALAAGIYVIWGPITERKKRRKGLVPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTLLHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQPRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDIYKYHLLGHKPSQHNPKLNKNPGPTLELQDGPGAPTPVLNQPGAPKTQIFMNGACSPSLLPTLSAPMPFPLPVVPDYSSSTYLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVLSSSAYLLFYERVLSRMQHQSQECKSEE
  
Inhibitor
Name:
BDBM512298
Synonyms:
US11084821, Example 27 | rac-(4aR,7aS)-4-(2-Cyano-[2,3′-bipyridin]-6′-yl)hexahydropyrrolo[3,4-b][1,4]oxazine-6(2H)-carbonitrile | rac-(4aR,7aS)-4-(2-Cyano-[2,3'-bipyridin]-6'-yl)hexahydropyrrolo[3,4-b][1,4]oxazine-6(2H)-carbonitrile
Type:
Small organic molecule
Emp. Form.:
C18H18N6O
Mol. Mass.:
334.3751
SMILES:
N#CN1C[C@@H]2OCCN([C@@H]2C1)c1ccc(cn1)C1(NC=CC=C1)C#N |c:22,24|
Structure:
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