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Target
Non-receptor tyrosine-protein kinase TYK2 [833-1187]
Ligand
BDBM50069344
Substrate
n/a
Meas. Tech.
TYK2 Kinase Assay
IC50
43±n/a nM
Citation
 Brasca, MG; Bindi, S; Caldarelli, M; Nesi, M; Orrenius, SC; Panzeri, A Substituted pyrroles active as kinases inhibitors US Patent  US9688661 Publication Date 6/27/2017 
Target
Name:
Non-receptor tyrosine-protein kinase TYK2 [833-1187]
Synonyms:
Non-receptor tyrosine-protein kinase TYK2 (TYK2) | TYK2 | TYK2_HUMAN
Type:
Protein
Mol. Mass.:
40613.06
Organism:
Homo sapiens (Human)
Description:
Human TYK2 variant (833-1187 aa)
Residue:
355
Sequence:
LPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
  
Inhibitor
Name:
BDBM50069344
Synonyms:
CHEMBL3403537 | US9688661, 4-(5-Chloro-2-methylphenyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrrole-3-carboxamide (compd 270)
Type:
Small organic molecule
Emp. Form.:
C18H14ClN5O
Mol. Mass.:
351.79
SMILES:
Cc1ccc(Cl)cc1-c1cn(cc1C(N)=O)-c1ncnc2[nH]ccc12
Structure:
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