Reaction Details Report a problem with these data
Target
P2X purinoceptor 7
Ligand
BDBM459728
Substrate
n/a
Meas. Tech.
Evaluation of a Human P2X7 Receptor Inhibitory Activity
IC50
2.00±n/a nM
Citation
 Ogawa, T; Kai, H; Hirai, K 6-membered heterocyclic derivatives and pharmaceutical composition comprising the same US Patent  US11124486 Publication Date 9/21/2021 
Target
Name:
P2X purinoceptor 7
Synonyms:
ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor
Type:
Protein
Mol. Mass.:
68602.85
Organism:
Homo sapiens (Human)
Description:
Q99572
Residue:
595
Sequence:
MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISSVHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCPEYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPALLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGDNFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYKENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSSNCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRSLQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCGSCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDSTNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
  
Inhibitor
Name:
BDBM459728
Synonyms:
US10774051, Compound I-0836 | US11124486, Compound I-0836
Type:
Small organic molecule
Emp. Form.:
C20H16F5N3O2
Mol. Mass.:
425.352
SMILES:
Cc1cc(OC(F)F)c(C)cc1Nc1nc(=O)c(F)cn1Cc1cc(F)cc(F)c1
Structure:
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