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Target
S-adenosylmethionine synthase isoform type-2
Ligand
BDBM508350
Substrate
n/a
Meas. Tech.
Phosphate Sensor Fluorescence Assay
IC50
<200±n/a nM
Citation
 Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE 2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors US Patent  US11130759 Publication Date 9/28/2021 
Target
Name:
S-adenosylmethionine synthase isoform type-2
Synonyms:
AMS2 | AdoMet synthase 2 | MAT 2 | MAT-II | MAT2A | MATA2 | METK2_HUMAN | Methionine adenosyltransferase 2 | Methionine adenosyltransferase II
Type:
Protein
Mol. Mass.:
43659.65
Organism:
Human
Description:
P31153
Residue:
395
Sequence:
MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
  
Inhibitor
Name:
BDBM508350
Synonyms:
1-(3-chloropyridin-2-yl)-7-(1,1- difluoroethyl)-4-(methylamino)- quinazolin-2(1H)-one | US11046691, Compound 661 | US11084798, Cpd No 661 | US11130759, Cpd. No. 661
Type:
Small organic molecule
Emp. Form.:
C16H13ClF2N4O
Mol. Mass.:
350.75
SMILES:
CNc1nc(=O)n(-c2ncccc2Cl)c2cc(ccc12)C(C)(F)F |(.62,5.03,;1.95,4.26,;1.95,2.72,;3.29,1.95,;3.29,.41,;4.62,-.36,;1.95,-.36,;1.95,-1.9,;.62,-2.67,;.62,-4.21,;1.95,-4.98,;3.29,-4.21,;3.29,-2.67,;4.62,-1.9,;.62,.41,;-.72,-.36,;-2.05,.41,;-2.05,1.95,;-.72,2.72,;.62,1.95,;-3.38,-.36,;-2.61,-1.7,;-4.72,-1.13,;-4.15,.97,)|
Structure:
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