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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM520298
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Competition Assay
Ki
8.70±n/a nM
Citation
 Zhuo, J; Leal, R; Shetty, R; Luengo, J; Combs, AP; Wei, P Spiro-sulfonamide derivatives as inhibitors of myeloid cell leukemia-1 (MCL-1) protein US Patent  US11130769 Publication Date 9/28/2021 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM520298
Synonyms:
2-(1,5-Dimethylpyrazol-3-yl)-N-[(3S)-6′-chloro-5-(cyclobutylmethyl)spiro[2,4-dihydro-1,5-benzoxazepine-3,1′-tetralin]-7-yl]sulfonyl-acetamide | US11130769, Ex. No. 15
Type:
Small organic molecule
Emp. Form.:
C30H35ClN4O4S
Mol. Mass.:
583.141
SMILES:
Cc1cc(CC(=O)NS(=O)(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(CC4CCC4)c3c2)nn1C |r|
Structure:
Search PDB for entries with ligand similarity: