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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM520308
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Competition Assay
Ki
9.00±n/a nM
Citation
 Zhuo, J; Leal, R; Shetty, R; Luengo, J; Combs, AP; Wei, P Spiro-sulfonamide derivatives as inhibitors of myeloid cell leukemia-1 (MCL-1) protein US Patent  US11130769 Publication Date 9/28/2021 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM520308
Synonyms:
(1S,1′R,2′R)-6-Chloro-3,4-dihydro-2H-spiro[naphthalene-1,3′-5,10-dithia-9-aza-1(5,7)-benzo[b][1,4]oxazepina-6(1,3)-benzena-3(1,2)-cyclobutanacyclodecaphan]-8′-one 10′,10′-dioxide | US11130769, Ex. No. 25
Type:
Small organic molecule
Emp. Form.:
C32H33ClN2O4S2
Mol. Mass.:
609.198
SMILES:
Clc1ccc2c(CCCC22COc3ccc4cc3N(C2)CC2CC[C@H]2CSc2cccc(CC(=O)NS4(=O)=O)c2)c1 |r|
Structure:
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