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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM520580
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Competition Assay
Ki
<100±n/a nM
Citation
 Zhuo, J; Leal, R; Shetty, R; Luengo, J; Combs, AP; Wei, P Spiro-sulfonamide derivatives as inhibitors of myeloid cell leukemia-1 (MCL-1) protein US Patent  US11130769 Publication Date 9/28/2021 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM520580
Synonyms:
(3R,6R,7S,8E,22S)-6′-Chloro-7-[2-[4-(2-methoxyethyl)-1,4-diazepan-1-yl]ethoxy]-11,12,12-trimethyl-15,15-dioxo-spiro[20-oxa-15-thia-1,11,14-triazatetracyclo[14.7.2.03,6.019,24]pentacosa-8,16,18,24-tetraene-22,1′-tetralin]-13-one | US11130769, Ex. No. 277
Type:
Small organic molecule
Emp. Form.:
C42H60ClN5O6S
Mol. Mass.:
798.474
SMILES:
COCCN1CCCN(CCO[C@H]2\C=C\CN(C)C(C)(C)C(=O)NS(=O)(=O)c3ccc4OC[C@]5(CCCc6cc(Cl)ccc56)CN(C[C@@H]5CC[C@@H]25)c4c3)CC1 |r,t:13|
Structure:
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