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Target
Cyclin-dependent kinase 6
Ligand
BDBM525721
Substrate
n/a
Meas. Tech.
In Vitro Kinase Inhibition Assay
IC50
1.000±n/a nM
Citation
 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J Heterocyclic compounds as kinase inhibitors US Patent  US11174252 Publication Date 11/16/2021 
Target
Name:
Cyclin-dependent kinase 6
Synonyms:
CDK6 | CDK6_HUMAN | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE
Type:
Enzyme Subunit
Mol. Mass.:
36937.42
Organism:
Homo sapiens (Human)
Description:
Q00534
Residue:
326
Sequence:
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA
  
Inhibitor
Name:
BDBM525721
Synonyms:
US11174252, Compound 16
Type:
Small organic molecule
Emp. Form.:
C24H25F2N5O
Mol. Mass.:
437.485
SMILES:
CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc3CCNCc3c2)ncc1F
Structure:
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