Reaction Details Report a problem with these data
Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM526961
Substrate
n/a
Meas. Tech.
Cell-Based (HeLa) Assay for Measurement of IDO1 Inhibition
EC50
58.0±n/a nM
Citation
 Bartlett, MJ; Corkey, BK; Elbel, KM; Kalla, RV; Li, X; Perry, T Therapeutic heterocyclic compounds US Patent  US11186579 Publication Date 11/30/2021 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM526961
Synonyms:
N-(4-fluorophenyl)-5-(3-(5-fluoropyridin-3- yl)imidazo[1,2-a]pyridin-8-yl)-2- (trifluoromethyl)benzamide | US11186579, Example 26
Type:
Small organic molecule
Emp. Form.:
C26H15F5N4O
Mol. Mass.:
494.4155
SMILES:
Fc1ccc(NC(=O)c2cc(ccc2C(F)(F)F)-c2cccn3c(cnc23)-c2cncc(F)c2)cc1
Structure:
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