Reaction Details Report a problem with these data
Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM526967
Substrate
n/a
Meas. Tech.
Cell-Based (HeLa) Assay for Measurement of IDO1 Inhibition
EC50
19.0±n/a nM
Citation
Bartlett, MJ; Corkey, BK; Elbel, KM; Kalla, RV; Li, X; Perry, T Therapeutic heterocyclic compounds US Patent US11186579 Publication Date 11/30/2021
More Info.:
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
Inhibitor
Name:
BDBM526967
Synonyms:
5-(3-chloro-1-(2,3-difluorophenyl)imidazo[1,5- a]pyridin-5-yl)-N-(4-fluorophenyl)-2- (trifluoromethyl)benzamide | US11186579, Example 32
Type:
Small organic molecule
Emp. Form.:
C27H14ClF6N3O
Mol. Mass.:
545.863
SMILES:
Fc1ccc(NC(=O)c2cc(ccc2C(F)(F)F)-c2cccc3c(nc(Cl)n23)-c2cccc(F)c2F)cc1