Reaction Details Report a problem with these data
Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM526968
Substrate
n/a
Meas. Tech.
Cell-Based (HeLa) Assay for Measurement of IDO1 Inhibition
EC50
15.0±n/a nM
Citation
Bartlett, MJ; Corkey, BK; Elbel, KM; Kalla, RV; Li, X; Perry, T Therapeutic heterocyclic compounds US Patent US11186579 Publication Date 11/30/2021
More Info.:
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
Inhibitor
Name:
BDBM526968
Synonyms:
5-(3-(2,3-difluorophenyl)imidazo[1,2- b]pyridazin-8-yl)-N-(4-fluorophenyl)-2- methylbenzamide | US11186579, Example 33
Type:
Small organic molecule
Emp. Form.:
C26H17F3N4O
Mol. Mass.:
458.4346
SMILES:
Cc1ccc(cc1C(=O)Nc1ccc(F)cc1)-c1ccnn2c(cnc12)-c1cccc(F)c1F