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Target
Receptor-interacting serine/threonine-protein kinase 2
Ligand
BDBM303825
Substrate
n/a
Meas. Tech.
V9103X ADP-Glo Kinase Assay
IC50
3.00±n/a nM
Citation
 Liu, P; Miller, CA; Yu, M; Zhang, Z; Ruppel, S; Padyana, AK Substituted benzamides as RIPK2 inhibitors US Patent  US10138241 Publication Date 11/27/2018 
Target
Name:
Receptor-interacting serine/threonine-protein kinase 2
Synonyms:
CARDIAK | RICK | RIP2 | RIPK2 | RIPK2_HUMAN | Serine/threonine-protein kinase RIPK2 | Tyrosine-protein kinase RIPK2 | receptor-interacting serine/threonine-protein kinase 2
Type:
Protein
Mol. Mass.:
61201.30
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
540
Sequence:
MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM
  
Inhibitor
Name:
BDBM303825
Synonyms:
US10138241, Example 9 | US11130754, Example 9
Type:
Small organic molecule
Emp. Form.:
C20H16ClFN6O2
Mol. Mass.:
426.831
SMILES:
COc1cn2c(cnc2cn1)-n1cc(cn1)-c1cc(C(=O)NC2CC2)c(F)cc1Cl
Structure:
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