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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM527817
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
3.30±n/a nM
Citation
 Chin, G; Clarke, MO; Han, X; Hansen, T; Hu, YE; Koltun, D; McFadden, R; Mish, MR; Parkhill, EQ; Sperandio, D; Xu, L; Yang, H Imidazopyrimidine derivatives US Patent  US11179397 Publication Date 11/23/2021 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
593
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM527817
Synonyms:
(2S,4R)-4-amino-8- (8-(2,3- dichlorophenyl)-7- methylimidazo[1,2- c]pyrimidin-5-yl)-8- azaspiro[4.5]decan- 2-ol | US11179397, Example 34
Type:
Small organic molecule
Emp. Form.:
C22H25Cl2N5O
Mol. Mass.:
446.373
SMILES:
Cc1nc(N2CCC3(C[C@H](O)C[C@H]3N)CC2)n2ccnc2c1-c1cccc(Cl)c1Cl |r,wU:9.9,wD:12.13,(-1.22,3.55,;-1.22,2.01,;.11,1.24,;.11,-.3,;1.45,-1.07,;1.45,-2.61,;2.78,-3.38,;4.12,-2.61,;4.28,-4.14,;5.78,-4.46,;6.41,-5.86,;6.55,-3.12,;5.52,-1.98,;5.84,-.47,;4.12,-1.07,;2.78,-.3,;-1.22,-1.07,;-1.54,-2.57,;-3.07,-2.73,;-3.7,-1.33,;-2.55,-.3,;-2.55,1.24,;-3.89,2.01,;-5.22,1.24,;-6.55,2.01,;-6.55,3.55,;-5.22,4.32,;-5.22,5.86,;-3.89,3.55,;-2.55,4.32,)|
Structure:
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