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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM527906
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
6.80±n/a nM
Citation
 Chin, G; Clarke, MO; Han, X; Hansen, T; Hu, YE; Koltun, D; McFadden, R; Mish, MR; Parkhill, EQ; Sperandio, D; Xu, L; Yang, H Imidazopyrimidine derivatives US Patent  US11179397 Publication Date 11/23/2021 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
593
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM527906
Synonyms:
(3S,4S)-8-(8-((7- methoxyquinolin- 4-yl)thio) imidazo[1,2-c] pyrimidin-5- yl)-3-methyl-2- oxa-8- azaspiro[4.5] decan-4-amine | US11179397, Example 123
Type:
Small organic molecule
Emp. Form.:
C25H28N6O2S
Mol. Mass.:
476.594
SMILES:
COc1ccc2c(Sc3cnc(N4CCC5(CO[C@@H](C)[C@H]5N)CC4)n4ccnc34)ccnc2c1 |r|
Structure:
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