Reaction Details Report a problem with these data
Target
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
Ligand
BDBM528349
Substrate
n/a
Meas. Tech.
Ca2+-Calmodulin Dependent PDE Enzyme Assays
IC50
0.343±0.765 nM
Citation
 Genin, MJ; Holloway, WG; Johnston, RD; Morphy, JR; Shi, Q [1,2,4]Triazolo[4,3-A]pyrazin-6(5H)-one derivatives US Patent  US11180503 Publication Date 11/23/2021 
Target
Name:
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
Synonyms:
61 kDa Cam-PDE | Calcium/calmodulin-dependent 3',5'-cyclic phosphodiesterase 1A | Cam-PDE 1A | PDE1A | PDE1A_HUMAN | hCam-1
Type:
Protein
Mol. Mass.:
61245.69
Organism:
Homo sapiens (Human)
Description:
P54750
Residue:
535
Sequence:
MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ
  
Inhibitor
Name:
BDBM528349
Synonyms:
9-([1,1'- Bi(cyclopropan)]-1- yl)-5-butyl-2,3- dimethylpyrido[3,2- e][1,2,4]triazolo[4,3- a]pyrazin-6(5H)-one | US11180503, Example 7
Type:
Small organic molecule
Emp. Form.:
C20H25N5O
Mol. Mass.:
351.4454
SMILES:
CCCCn1c2cc(C)c(C)nc2n2c(nnc2c1=O)C1(CC1)C1CC1
Structure:
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