Reaction Details Report a problem with these data
Target
Metallo-beta-lactamase VIM-2
Ligand
BDBM530960
Substrate
n/a
Meas. Tech.
Enzyme Activity: Determination of IC50
IC50
0.740±n/a nM
Citation
 Pasternak, A; Dong, S; Scott, JD; Tang, H; Zhao, Z; Yang, D; Gu, X; Jiang, J; Xiao, L Metallo-beta-lactamase inhibitors and methods of use thereof US Patent  US11207312 Publication Date 12/28/2021 
Target
Name:
Metallo-beta-lactamase VIM-2
Synonyms:
Beta-lactamase VIM-2 | Metallo-beta-lactamase VIM-2 (VIM-2)
Type:
Protein
Mol. Mass.:
28318.00
Organism:
Pseudomonas aeruginosa (g-Proteobacteria)
Description:
n/a
Residue:
266
Sequence:
MFKLLSKLLVYLTASIMAIASPLAFSVDSSGEYPTVSEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNRSVVE
  
Inhibitor
Name:
BDBM530960
Synonyms:
1-{4-[(3R)-pyrrolidin-3- ylsulfamoyl]-3-sulfamoyl-2- (1H-tetrazol-5- yl)phenyl}pyrrolidine-3- carboxamide | US11207312, Example 92
Type:
Small organic molecule
Emp. Form.:
C16H23N9O5S2
Mol. Mass.:
485.541
SMILES:
NC(=O)C1CCN(C1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1 |r|
Structure:
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