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Target
Metallo-beta-lactamase VIM-2
Ligand
BDBM530978
Substrate
n/a
Meas. Tech.
Enzyme Activity: Determination of IC50
IC50
0.470±n/a nM
Citation
 Pasternak, A; Dong, S; Scott, JD; Tang, H; Zhao, Z; Yang, D; Gu, X; Jiang, J; Xiao, L Metallo-beta-lactamase inhibitors and methods of use thereof US Patent  US11207312 Publication Date 12/28/2021 
Target
Name:
Metallo-beta-lactamase VIM-2
Synonyms:
Beta-lactamase VIM-2 | Metallo-beta-lactamase VIM-2 (VIM-2)
Type:
Protein
Mol. Mass.:
28318.00
Organism:
Pseudomonas aeruginosa (g-Proteobacteria)
Description:
n/a
Residue:
266
Sequence:
MFKLLSKLLVYLTASIMAIASPLAFSVDSSGEYPTVSEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNRSVVE
  
Inhibitor
Name:
BDBM530978
Synonyms:
4-[4-(pyridin-2- yloxy)piperidin-1-yl]-N1- [(3R)-pyrrolidin-3-yl]-3-(1H- tetrazol-5-yl)benzene-1,2- disulfonamide | US11207312, Example 110
Type:
Small organic molecule
Emp. Form.:
C21H27N9O5S2
Mol. Mass.:
549.626
SMILES:
NS(=O)(=O)c1c(ccc(N2CCC(CC2)Oc2ccccn2)c1-c1nnn[nH]1)S(=O)(=O)N[C@@H]1CCNC1 |r|
Structure:
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