Reaction Details Report a problem with these data
Target
Metallo-beta-lactamase VIM-2
Ligand
BDBM531037
Substrate
n/a
Meas. Tech.
Enzyme Activity: Determination of IC50
IC50
0.400±n/a nM
Citation
Pasternak, A; Dong, S; Scott, JD; Tang, H; Zhao, Z; Yang, D; Gu, X; Jiang, J; Xiao, L Metallo-beta-lactamase inhibitors and methods of use thereof US Patent US11207312 Publication Date 12/28/2021
More Info.:
Target
Name:
Metallo-beta-lactamase VIM-2
Synonyms:
Beta-lactamase VIM-2 | Metallo-beta-lactamase VIM-2 (VIM-2)
Type:
Protein
Mol. Mass.:
28318.00
Organism:
Pseudomonas aeruginosa (g-Proteobacteria)
Description:
n/a
Residue:
266
Sequence:
MFKLLSKLLVYLTASIMAIASPLAFSVDSSGEYPTVSEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNRSVVE
Inhibitor
Name:
BDBM531037
Synonyms:
(R)-4-(4-(1H-imidazol-4-yl)piperidin-1-yl)-N1-(3-amino-2-hydroxypropyl)-3-(1H-tetrazol-5-yl)benzene-1,2-disulfonamide | US11207312, Example 169
Type:
Small organic molecule
Emp. Form.:
C18H26N10O5S2
Mol. Mass.:
526.593
SMILES:
NC[C@@H](O)CNS(=O)(=O)c1ccc(N2CCC(CC2)c2c[nH]cn2)c(-c2nnn[nH]2)c1S(N)(=O)=O |r|