Reaction Details Report a problem with these data
Target
Metallo-beta-lactamase VIM-2
Ligand
BDBM531061
Substrate
n/a
Meas. Tech.
Enzyme Activity: Determination of IC50
IC50
0.750±n/a nM
Citation
 Pasternak, A; Dong, S; Scott, JD; Tang, H; Zhao, Z; Yang, D; Gu, X; Jiang, J; Xiao, L Metallo-beta-lactamase inhibitors and methods of use thereof US Patent  US11207312 Publication Date 12/28/2021 
Target
Name:
Metallo-beta-lactamase VIM-2
Synonyms:
Beta-lactamase VIM-2 | Metallo-beta-lactamase VIM-2 (VIM-2)
Type:
Protein
Mol. Mass.:
28318.00
Organism:
Pseudomonas aeruginosa (g-Proteobacteria)
Description:
n/a
Residue:
266
Sequence:
MFKLLSKLLVYLTASIMAIASPLAFSVDSSGEYPTVSEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNRSVVE
  
Inhibitor
Name:
BDBM531061
Synonyms:
(R)-N1-(3-amino-2-hydroxypropyl)- 4-(4-(3-aminopropyl)piperidin-1-yl)- 3-(2H-tetrazol-5-yl)benzene-1,2- disulfonamide | US11207312, Example 193
Type:
Small organic molecule
Emp. Form.:
C18H31N9O5S2
Mol. Mass.:
517.626
SMILES:
NCCCC1CCN(CC1)c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)NC[C@H](O)CN |r|
Structure:
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