Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Eukaryotic translation initiation factor 4E-binding protein 1
Ligand
BDBM544984
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Assay
IC50
2.25±n/a nM
Citation
Sperry, S; Xiang, AX; Ernst, JT; Reich, SH; Sprengeler, PA; Shaghafi, M; Michels, T; Nilewski, C; Tran, CV; Packard, GK; Grubbs, A; Urkalan, K; Mukaiyama, T EIF4E-inhibiting compounds and methods US Patent US11286268 Publication Date 3/29/2022 More Info.:
Target
Name:
Eukaryotic translation initiation factor 4E-binding protein 1
Synonyms:
4EBP1_HUMAN | EIF4EBP1 | GFP-4EBP | GFP-4EBP1 | Green fluorescent protein-Eukaryotic initiation factor 4E (eIF4E) binding protein
Type:
Fusion protein
Mol. Mass.:
12578.35
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
118
Sequence:
MSGGSSCSQTPSRAIPATRRVVLGDGVQLPPGDYSTTPGGTLFSTTPGGTRIIYDRKFLMECRNSPVTKTPPRDLPTIPGVTSPSSDEPPMEASQSHLRNSPEDKRAGGEESQFEMDI
Inhibitor
Name:
BDBM544984
Synonyms:
US11286268, Compound 469
Type:
Small organic molecule
Emp. Form.:
C35H25ClF3N5O4S
Mol. Mass.:
704.117
SMILES:
Cc1cc(c(C)cn1)-c1c(cc2nc(C)n(CCOc3ccc(Cl)cc3-c3cc(C)nc4c(csc34)C(O)=O)c(=O)c2c1C#N)C(F)(F)F |(-10,-2.69,;-8.67,-1.93,;-7.34,-2.69,;-6,-1.93,;-6,-.38,;-4.67,.38,;-7.34,.38,;-8.67,-.38,;-4.67,-2.69,;-4.67,-4.23,;-3.33,-5,;-2,-4.23,;-.67,-5,;.67,-4.23,;2,-5,;.67,-2.69,;2,-1.93,;2,-.38,;3.33,.38,;3.33,1.93,;2,2.69,;2,4.23,;3.33,5,;3.33,6.54,;4.67,4.23,;4.67,2.69,;6,1.93,;7.34,2.69,;8.67,1.93,;10,2.69,;8.67,.38,;7.34,-.38,;7.02,-1.89,;5.48,-2.05,;4.86,-.65,;6,.38,;8.05,-3.04,;7.57,-4.5,;9.55,-2.72,;-.67,-1.93,;-.67,-.38,;-2,-2.69,;-3.33,-1.93,;-3.33,-.38,;-3.33,1.15,;-6,-5,;-7.34,-4.23,;-6,-6.54,;-7.34,-5.78,)|
Structure:
