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Target
Platelet-activating factor receptor
Ligand
BDBM552615
Substrate
n/a
Meas. Tech.
EVALUATION OF THE INHIBITION OF PAFR ACTIVATION
IC50
0.40±n/a nM
Citation
 Matthias, E; Kristina, WM; Juergen, P; Ferenc, K; Leo, T; Siegfried, TC; Dieter, W CYCLOPENTATHIOPHENE CARBOXAMIDE DERIVATIVES AS PLATELET ACTIVATING FACTOR RECEPTOR ANTAGONISTS WIPO 0:0 (2022) [PubMed] 
Target
Name:
Platelet-activating factor receptor
Synonyms:
PAF Platelet activating factor | PAF-R | PAFR | PTAFR | PTAFR_HUMAN | Platelet activating factor receptor | Platelet-activating factor receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39219.60
Organism:
Homo sapiens (Human)
Description:
PAF Platelet activating factor PTAFR HUMAN::P25105
Residue:
342
Sequence:
MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLTMADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVTRPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKGSVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN
  
Inhibitor
Name:
BDBM552615
Synonyms:
WO2022101377, Example 14
Type:
Small organic molecule
Emp. Form.:
C27H23ClF3N5OS
Mol. Mass.:
558.018
SMILES:
Cc1nnc2CN[C@H](c3c4C[C@@H](Cc4sc3-n12)C(=O)NCc1ccc(cc1)C(F)(F)F)c1ccccc1Cl
Structure:
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