Reaction Details Report a problem with these data
Target
Pro-cathepsin H
Ligand
BDBM453289
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
1550±n/a nM
Citation
 Konradi, AW; Galemmo, Jr., RA; Dominy, SS; Lynch, CC; Holsinger, LJ Ketone inhibitors of lysine gingipain US Patent  US11325884 Publication Date 5/10/2022 
Target
Name:
Pro-cathepsin H
Synonyms:
CATH_HUMAN | CBSP | CPSB | CTSH | Cathepsin H | Cathepsin H heavy chain | Cathepsin H light chain | Cathepsin H mini chain
Type:
PROTEIN
Mol. Mass.:
37402.31
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1459870
Residue:
335
Sequence:
MWATLPLLCAGAWLLGVPVCGAAELCVNSLEKFHFKSWMSKHRKTYSTEEYHHRLQTFASNWRKINAHNNGNHTFKMALNQFSDMSFAEIKHKYLWSEPQNCSATKSNYLRGTGPYPPSVDWRKKGNFVSPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQDFNNHGCQGGLPSQAFEYILYNKGIMGEDTYPYQGKDGYCKFQPGKAIGFVKDVANITIYDEEAMVEAVALYNPVSFAFEVTQDFMMYRTGIYSSTSCHKTPDKVNHAVLAVGYGEKNGIPYWIVKNSWGPQWGMNGYFLIERGKNMCGLAACASYPIPLV
  
Inhibitor
Name:
BDBM453289
Synonyms:
US10730826, Compound 2a | US11325884, Compound 2a
Type:
Small organic molecule
Emp. Form.:
C19H26F2N2O3
Mol. Mass.:
368.4181
SMILES:
NCCCCC(NC(=O)C1CCCC1)C(=O)COc1c(F)cccc1F
Structure:
Search PDB for entries with ligand similarity: