Reaction Details Report a problem with these data
Target
Lysophosphatidic acid receptor 1
Ligand
BDBM557842
Substrate
n/a
Meas. Tech.
LPAR1 Membrane Binding Assay
Ki
46.2±n/a nM
Citation
 Ma, T; Wu, L; Zhang, X Lysophosphatidic acid receptor 1 (LPAR1) inhibitor compounds US Patent  US11365185 Publication Date 6/21/2022 
Target
Name:
Lysophosphatidic acid receptor 1
Synonyms:
EDG2 | LPA receptor 1 | LPA-1 | LPA1 | LPAR1 | LPAR1_HUMAN | Lysophosphatidic acid receptor 1 (LPA1) | Lysophosphatidic acid receptor Edg-2
Type:
Enzyme
Mol. Mass.:
41120.55
Organism:
Homo sapiens (Human)
Description:
Q92633
Residue:
364
Sequence:
MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRSENPTGPTEGSDRSASSLNHTILAGVHSNDHSVV
  
Inhibitor
Name:
BDBM557842
Synonyms:
US11365185, Example 24B
Type:
Small organic molecule
Emp. Form.:
C25H25N7O2
Mol. Mass.:
455.5117
SMILES:
CC(C)c1cncc(Nc2c(cnn2C)-c2ccc(cn2)-c2ccc(cn2)C2(CC2)C(O)=O)n1 |$;;;;;;;;N;;;;;;;;;;;;;;;;;;;;;;;;;$|
Structure:
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