Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM559669
Substrate
n/a
Meas. Tech.
IP-One Assay
IC50
0.18±n/a nM
Citation
 L., BS; Ping, C; James, CD; Jian, L; T., RM; Li, X; Dexi, Y; Shishi, L 3-AMINO PYRROLIDINE AND PIPERIDINE MACROCYCLIC OREXIN RECEPTOR AGONISTS WIPO 0:0 (2022) [PubMed] 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM559669
Synonyms:
WO2022109117, Example 14
Type:
Small organic molecule
Emp. Form.:
C24H37N3O5S
Mol. Mass.:
479.633
SMILES:
C[C@@H]1C[C@H](NS(=O)(=O)N(C)C)[C@@H]2CO[C@H]3CC[C@H](CC3)c3cccc(OCCCC(=O)N12)c3 |wU:14.14,17.16,wD:1.0,3.3,11.33,(16.68,5.97,;16.31,4.49,;17.28,3.33,;16.47,2.04,;17.03,.63,;18.54,.42,;18.75,1.92,;18.32,-1.09,;20.04,.2,;20.6,-1.21,;20.98,1.39,;15,2.42,;14.51,.92,;13.48,-.31,;11.86,-.64,;10.53,-1.48,;9.11,-.9,;8.9,.66,;10.19,1.5,;11.57,.86,;7.79,1.85,;6.23,1.94,;5.51,3.29,;6.25,4.61,;7.8,4.57,;8.68,5.84,;9.98,6.67,;11.51,6.83,;12.99,6.38,;14.19,5.37,;15.38,6.3,;14.9,3.93,;8.53,3.21,)|
Structure:
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