Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM559670
Substrate
n/a
Meas. Tech.
IP-One Assay
IC50
0.10±n/a nM
Citation
 L., BS; Ping, C; James, CD; Jian, L; T., RM; Li, X; Dexi, Y; Shishi, L 3-AMINO PYRROLIDINE AND PIPERIDINE MACROCYCLIC OREXIN RECEPTOR AGONISTS WIPO 0:0 (2022) [PubMed] 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM559670
Synonyms:
WO2022109117, Example 15 | WO2022109117, Example 17
Type:
Small organic molecule
Emp. Form.:
C23H35N3O6S
Mol. Mass.:
481.606
SMILES:
C[C@@H]1C[C@H](NS(=O)(=O)N(C)C)[C@@H]2CO[C@H]3CC[C@H](CC3)c3cccc(OCCOC(=O)N12)c3 |wU:14.14,17.16,wD:1.0,3.3,11.33,(16.49,5.93,;16.12,4.46,;17.09,3.29,;16.28,2.01,;16.85,.6,;18.35,.38,;18.57,1.88,;18.13,-1.12,;19.85,.16,;20.41,-1.25,;20.79,1.36,;14.81,2.38,;14.33,.88,;13.29,-.35,;11.68,-.68,;10.35,-1.51,;8.92,-.93,;8.71,.62,;10,1.46,;11.38,.83,;7.6,1.81,;6.04,1.9,;5.32,3.25,;6.06,4.57,;7.61,4.53,;8.49,5.8,;9.79,6.63,;11.33,6.8,;12.81,6.34,;14,5.33,;15.2,6.26,;14.71,3.89,;8.34,3.17,)|
Structure:
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