Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM559674
Substrate
n/a
Meas. Tech.
IP-One Assay
IC50
0.30±n/a nM
Citation
 L., BS; Ping, C; James, CD; Jian, L; T., RM; Li, X; Dexi, Y; Shishi, L 3-AMINO PYRROLIDINE AND PIPERIDINE MACROCYCLIC OREXIN RECEPTOR AGONISTS WIPO 0:0 (2022) [PubMed] 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM559674
Synonyms:
WO2022109117, Example 19
Type:
Small organic molecule
Emp. Form.:
C25H39N3O5S
Mol. Mass.:
493.659
SMILES:
C[C@@H]1C[C@H](NS(=O)(=O)N(C)C)[C@@H]2CO[C@H]3CC[C@H](CC3)c3cccc(OCCCCC(=O)N12)c3 |wD:3.3,14.14,17.16,11.34,1.0,(17.21,6.5,;16.71,5.07,;17.57,3.81,;16.65,2.61,;17.08,1.15,;18.56,.8,;18.91,2.28,;18.21,-.68,;20.04,.45,;20.47,-1.01,;21.08,1.55,;15.21,3.11,;14.61,1.66,;13.46,.58,;11.91,.29,;11.65,1.81,;10.23,2.36,;8.97,1.46,;9.26,-.08,;10.68,-.66,;7.76,2.55,;6.2,2.47,;5.29,3.7,;5.94,5.08,;7.47,5.28,;8.17,6.68,;9.32,7.72,;10.79,8.16,;12.33,8.02,;13.7,7.32,;14.73,6.15,;16.05,6.91,;15.25,4.63,;8.32,4,)|
Structure:
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