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Target
Mitogen-activated protein kinase 6
Ligand
BDBM365040
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
<0.020±n/a nM
Citation
 Kolesnikov, A; Do, S Serine/threonine kinase inhibitors US Patent  US11376260 Publication Date 7/5/2022 
Target
Name:
Mitogen-activated protein kinase 6
Synonyms:
ERK3 | MAPK6 | MK06_HUMAN | PRKM6
Type:
PROTEIN
Mol. Mass.:
82643.07
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774367
Residue:
721
Sequence:
MAEKFESLMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYMSIYSFPMDEPISSHPFHIEDEVDDILLMDETHSHIYNWERYHDCQFSEHDWPVHNNFDIDEVQLDPRALSDVTDEEEVQVDPRKYLDGDREKYLEDPAFDTNYSTEPCWQYSDHHENKYCDLECSHTCNYKTRSSSYLDNLVWRESEVNHYYEPKLIIDLSNWKEQSKEKSDKKGKSKCERNGLVKAQIALEEASQQLAGKEREKNQGFDFDSFIAGTIQLSSQHEPTDVVDKLNDLNSSVSQLELKSLISKSVSQEKQEKGMANLAQLEALYQSSWDSQFVSGGEDCFFINQFCEVRKDEQVEKENTYTSYLDKFFSRKEDTEMLETEPVEDGKLGERGHEEGFLNNSGEFLFNKQLESIGIPQFHSPVGSPLKSIQATLTPSAMKSSPQIPHQTYSSILKHLN
  
Inhibitor
Name:
BDBM365040
Synonyms:
4-(3-(3-fluoro-4- methoxybenzyl)-4,5-dihydro- 3H-1,2,2a1,5- tetraazaacenaphthylen-7-yl)- N-(1-methyl-1H-pyrazol-5- yl)pyrimidin-2-amine | US10278975, Compound I-12 R | US11376260, Example I-12S | US9867833, Compound I-12(S)
Type:
Small organic molecule
Emp. Form.:
C24H22FN9O
Mol. Mass.:
471.4896
SMILES:
COc1ccc(C[C@H]2CNc3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)n2)cc1F |r|
Structure:
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