Reaction Details Report a problem with these data
Target
Mitogen-activated protein kinase 6
Ligand
BDBM383254
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
<0.020±n/a nM
Citation
 Kolesnikov, A; Do, S Serine/threonine kinase inhibitors US Patent  US11376260 Publication Date 7/5/2022 
Target
Name:
Mitogen-activated protein kinase 6
Synonyms:
ERK3 | MAPK6 | MK06_HUMAN | PRKM6
Type:
PROTEIN
Mol. Mass.:
82643.07
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774367
Residue:
721
Sequence:
MAEKFESLMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYMSIYSFPMDEPISSHPFHIEDEVDDILLMDETHSHIYNWERYHDCQFSEHDWPVHNNFDIDEVQLDPRALSDVTDEEEVQVDPRKYLDGDREKYLEDPAFDTNYSTEPCWQYSDHHENKYCDLECSHTCNYKTRSSSYLDNLVWRESEVNHYYEPKLIIDLSNWKEQSKEKSDKKGKSKCERNGLVKAQIALEEASQQLAGKEREKNQGFDFDSFIAGTIQLSSQHEPTDVVDKLNDLNSSVSQLELKSLISKSVSQEKQEKGMANLAQLEALYQSSWDSQFVSGGEDCFFINQFCEVRKDEQVEKENTYTSYLDKFFSRKEDTEMLETEPVEDGKLGERGHEEGFLNNSGEFLFNKQLESIGIPQFHSPVGSPLKSIQATLTPSAMKSSPQIPHQTYSSILKHLN
  
Inhibitor
Name:
BDBM383254
Synonyms:
4-(9-(2-chlorobenzyl)-8,9- dihydro-7H-6-oxa-1,2,2a1- triazabenzo[cd]azulen-4-yl)- N-(1-methyl-1H-pyrazol-5- yl)pyridin-2-amine | US10278975, Compound I-30 S | US10278975, Compound I-60 R | US11376260, Example I-30S
Type:
Small organic molecule
Emp. Form.:
C25H22ClN7O
Mol. Mass.:
471.941
SMILES:
Cn1nccc1Nc1cc(ccn1)-c1cc2OCC[C@H](Cc3ccccc3Cl)c3nnc(c1)n23 |r|
Structure:
Search PDB for entries with ligand similarity: