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Target
Arginase-1
Ligand
BDBM290420
Substrate
n/a
Meas. Tech.
Inhibition of Arginase
IC50
125±n/a nM
Citation
 Van Zandt, M; Jagdmann, GE Arginase inhibitors as therapeutics US Patent  US11389464 Publication Date 7/19/2022 
Target
Name:
Arginase-1
Synonyms:
ARG1 | ARGI1_HUMAN | Liver-type arginase | Type I arginase
Type:
PROTEIN
Mol. Mass.:
34737.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_978893
Residue:
322
Sequence:
MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYLNPPK
  
Inhibitor
Name:
BDBM290420
Synonyms:
(3R,4S)-3-amino-4-(3-boronopropyl)-1-(7-chloro-1,2,3,4- tetrahydroisoquinoline-3-carbonyl)pyrrolidine-3-carboxylic acid | US10098902, Example 56 | US11389464, Example 56
Type:
Small organic molecule
Emp. Form.:
C18H25BClN3O5
Mol. Mass.:
409.672
SMILES:
N[C@]1(CN(C[C@@H]1CCCB(O)O)C(=O)C1Cc2ccc(Cl)cc2CN1)C(O)=O |r|
Structure:
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